tirzepatide vs semaglutide head-to-head trial SURPASS-2 (NEJM 2021) was the definitive head-to-head: tirzepatide vs semaglutide 1.0 mg (the maximum approved T2DM dose) in 1,879 patients with type 2 diabetes. All three tirzepatide doses produced superior HbA1c reductions

Name: tirzepatide vs semaglutide head-to-head trial SURPASS-2 (NEJM 2021) was the definitive head-to-head: tirzepatide vs semaglutide 1.0 mg (the maximum approved T2DM dose) in 1,879 patients with type 2 diabetes. All three tirzepatide doses produced superior HbA1c reductions
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Tirzepatide vs Semaglutide for Obesity NEJM, May 2025 Relevant to endocrinology, internal medicine, cardiology, obesity medicine Tirzepatide: 20.2% weight loss at 72 wks Semaglutide: 13.7% Greater waist reduction

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